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Direct Investment  + IPOs  | 
Caris Life Sciences Kicks Off IPO Roadshow, Eyes Up to $5.35B Valuation   

Caris Life Sciences Kicks Off IPO Roadshow, Eyes Up to $5.35B Valuation   

Caris Life Sciences, an Irving, TX-based AI-driven TechBio and precision medicine company, has initiated the roadshow for its initial public offering (IPO) of 23,529,412 shares of common stock. The company filed a Form S-1 with the SEC, granting underwriters a 30-day option to purchase up to 3,529,411 additional shares. The IPO price is expected to range from $16 to $18 per share, aiming for a valuation of $4.8 billion to $5.35 billion. Caris will list on the Nasdaq Global Select Market under the ticker “CAI.” 

Leading the offering are BofA Securities, J.P. Morgan, and Goldman Sachs & Co. LLC. They are joined by Citigroup, TD Cowen, Evercore ISI, and Guggenheim Securities as book-running managers, while BTIG and Wolfe | Nomura Alliance will act as co-managers. 

Caris specializes in molecular profiling and oncology diagnostics, having completed over 6.5 million tests for 849,000 unique cases. The firm collaborates with more than 100 biopharma companies and thousands of oncologists nationwide.  

The IPO follows a $168 million private financing round in April 2025, bringing its total capital raised since 2018 to $1.86 billion. Proceeds will support the continued development of Caris’ precision medicine platform, focusing on advancing tools for early cancer detection, diagnostics, and therapy selection. 

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About Joe Palmisano

Joe Palmisano is Editorial Director for Connect Money, where he brings nearly three decades experience of market insights as a financial journalist, analyst and senior portfolio manager for leading financial publications, advisory firms, and hedge funds. In his role as Editorial Director, Joe is responsible for the selection of content and creation of daily business news covering the financial markets, including Alternative Assets, Direct Investment and Financial Advisory services. Before joining Connect Money, Joe was a financial journalist for the Wall Street Journal, regularly publishing feature stories and trend pieces on the foreign exchange, global fixed income and equity markets. Joe parlayed his experience as a financial journalist into roles as a Senior Research Analyst and Portfolio Manager, writing daily and weekly market analysis and managing a FX and US equity portfolio. Joe was also a contributing writer for industry magazines and publications, including SFO Magazine and the CMT Association. Joe earned a B.S.B.A. in Finance from The American University. He holds the Chartered Market Technician (CMT) designation and is a member of the CFA Institute.

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